Viewpoints

• Science, Politics, and Over-the-Counter Emergency Contraception
• Physician Autonomy and Health Care Reform
• Affordable Care Act Litigation: The Supreme Court and the Future of Health Care Reform

Original Contribution

Lansoprazole for Children With Poorly Controlled Asthma: A Randomized Clinical Trial

To test the effect of treating asymptomatic gastroesophageal reflux (GER) on children with asthma, investigators randomized 306 children without GER to receive lansoprazole or placebo. In an editorial, Martinez discusses perils of therapeutic creep.

• » Abstract
• » Free Full Text
  
• » Editorial: Children, Asthma, and Proton Pump Inhibitors—Costs and Perils of Therapeutic Creep
• » Author Video/Audio Interview
• » JAMA Report Video

Original Contribution

Association Between BRCA1 and BRCA2 Mutations and Survival in Women With Invasive Epithelial Ovarian Cancer

In an analysis of pooled data from 26 studies, Bolton and colleagues compared survival among 3879 women with and without the BRCA1/2 gene who had invasive epithelial ovarian cancer. In an editorial, Hyman and Spriggs discuss implications of these findings.

• » Abstract
• » Full Text
• » Editorial: Unwrapping the Implications of BRCA1 and BRCA2 Mutations in Ovarian Cancer

Original Contribution

Serum Vaccine Antibody Concentrations in Children Exposed to Perfluorinated Compounds

Grandjean and colleagues assessed the effect of perfluorinated compounds (PFCs), which are present in food packaging, on diphtheria and tetanus immunizations in a cohort of 656 Faroe Island children.

• » Abstract
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Clinician's Corner | Grand Rounds

Caregiving Burden, Stress, and Health Effects Among Family Caregivers of Adult Cancer Patients

Bevans and Sternberg discuss stresses associated with caregiving required by family members and friends in the presentation of a 53-year-old woman shouldering the care of her husband while he underwent hematopoietic stem cell transplantation for acute myelogenous leukemia.

• » Abstract
• » Full Text
• » CME Course

Editorials

• Children, Asthma, and Proton Pump Inhibitors: Costs and Perils of Therapeutic Creep
• Unwrapping the Implications of BRCA1 and BRCA2 Mutations in Ovarian Cancer

A Piece of My Mind

Of What Am I Afraid?

"Marriage, divorce, coming out—none of these things are as life altering as gender change."

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Clinical Challenge

Cutaneous Granuloma

An 85-year-old man, receiving oral methylprednisolone therapy for Sjögren syndrome, had a 5-month history of papules, plaques, and subcutaneous nodules on his face, trunk, and extremities that had not responded to topical therapies. What would you do next?

• » Take the Clinical Challenge
• » View past Clinical Challenges

Readers Respond

A 14-Year-Old Struggling to Lose Weight

Ms K is a 14-year-old girl with a BMI of 40 and who has conflicts with her family over food choices. How would you manage her clinical care?

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• » View past Responses

Patient Page

Childhood Asthma

For your patients: Information about childhood asthma. Past JAMA Patient Pages are also freely available in English and Spanish.

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Complete Table of Contents