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Prospects and Implications for Clinical Medicine

Eric D. Green, MD, PhD; Robert H. Waterston, MD, PhD

JAMA. 1991;266(14):1966-1975.

Abstract
The recently initiated human genome project is a large international effort to elucidate the genetic architecture of the genomes of man and several model organisms. The initial phases of this endeavor involve the establishment of rough blueprints (maps) of the genetic landscape of these genomes, with the long-term goal of determining their precise nucleotide sequences and identifying the genes. The knowledge gained by these studies will provide a vital tool for the study of many biologic processes and will have a profound impact on clinical medicine.

(JAMA. 1991;266:1966-1975)

Author Affiliations
From the Departments of Genetics (Drs Green and Waterston), Pathology (Dr Green), and Internal Medicine (Dr Green), Washington University School of Medicine, St Louis, Mo.

Footnotes
Reprint requests to Department of Genetics, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110 (Dr Green).

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