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Bernard M. Y. Cheung, MA, MBBChir, PhD, MRCP(UK); Cyrus R. Kumana, MBBS, FRCP, FRCPC

JAMA. 1998;280:1983-1984.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

THE FAMILY of natriuretic peptides, which includes atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), has a regulatory and modulatory role in the cardiovascular system.^1-2 ANP and BNP are circulating cardiac hormones. ANP is synthesized by myocytes mainly in the atria and stored in granules. BNP, also known as brain natriuretic peptide because it was first isolated from porcine brain, is synthesized primarily by cardiac myocytes in the ventricles and is not stored to the same extent as ANP. The nucleic acid sequence of the BNP gene contains the destabilizing sequence TATTTAT, which suggests that the turnover of BNP messenger RNA (mRNA) is high and that BNP is synthesized in bursts. In response to stretching of the right atrium by increased venous pressure, stored ANP is immediately released from atrial granules, . . . [Full Text of this Article]

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Use of Natriuretic Peptide Assays

Therapeutic Applications

Conclusions

From the Department of Medicine, University of Hong Kong, Hong Kong, China. Dr Kumana is a member of the JAMA International Advisory Committee and editorial director of JAMA Southeast Asia.

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