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To the Editor: We previously reported the results of a genomic screen and initial follow-up in 54 multiplex families with late-onset Alzheimer disease (AD),¹ describing linkage to several markers in the centromeric region of chromosome 12. We have since reported linkage to chromosome 12 in an independent sample of Amish families.² Two research groups^3-4 recently reported additional evidence linking late-onset AD to chromosome 12. We now report our additional follow-up studies in relation to these articles.

Our original report focused on the centromeric region of chromosome 12, where evidence for linkage was indicated by our analysis of 54 large multiplex families with AD. To better localize the gene(s) involved with late-onset AD, we genotyped additional individuals in these families as well as additional markers surrounding loci D12S373 and D12S390, our initial region of significant linkage. Linkage analysis was performed using the methods described in our original report.¹

Two-point affecteds . . . [Full Text of this Article]

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