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Jack A. Yanovski, MD, PhD; Susan Z. Yanovski, MD

JAMA. 1999;282:1504-1506.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

More than 50% of US adults are overweight, with a body mass index of more than 25 kg/m² (calculated as weight in kilograms divided by the square of height in meters).¹ Even more concerning, the percentage of Americans who are obese (body mass index 30 kg/m²) has increased by more than 50% in the past 20 years, and the number of overweight children has doubled.² Most overweight individuals can successfully lose some of the weight, but the majority regain that weight within 5 years.³

Heritability studies suggest that as much as 70% of the variability in human body weight may be accounted for by genetic factors.^4-5 Yet it is virtually impossible that changes in the genetic background of Americans over the past 2 decades are solely responsible for the trend of increasing body weight. Easy access to good-tasting, high-fat foods⁶ . . . [Full Text of this Article]

Author Affiliations: Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child Health and Human Development (Dr J. Yanovski), and Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases (Dr S. Yanovski), National Institutes of Health, Bethesda, Md.

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