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Further Adventures of the Tubercle Bacillus
Kent A. Sepkowitz, MD
JAMA. 2000;284:1701-1702.
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In the past decade, tuberculosis (TB) has recaptured the interest of the medical community and the public because of its impolite refusal to go away when asked. The numbers are now familiar: 2 billion people worldwide with latent infection, 8 million new cases a year, and up to 2 million annual deaths.1 Equally alarming is the emergence of drug resistance to TB on all continents and the explosive interaction between Mycobacterium tuberculosis and the human immunodeficiency virus.
Despite the untold millions of cases of TB that have occurred through the centuries, surprisingly little is known about the transmission characteristics of the tubercle bacillus.2-3 It took the landmark studies by Riley et al in the 1950s,4-5 using untreated patients with cavitary disease, a cleverly designed system of air ducts, and hundreds of down-wind guinea pigs, to establish that TB was indeed spread through the air. Since then, . . . [Full Text of this Article]
Author Affiliation: Infectious Disease Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
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