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From the Inventory of Genes to Understanding Physiology and the Molecular Basis of Disease

Thomas D. Pollard, MD

JAMA. 2002;287:1725-1727.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The euphoria surrounding completion of the first draft of the sequence of the human genome signaled the beginning of the end of a historic phase of biomedical research that spanned the 20th century—the creation of an inventory of the molecules required for human life. Throughout the past 100 years, much knowledge was also learned about biological function but from a historical perspective the big story was the molecular inventory. Like the 19th-century biologists, who enumerated the variety of biological species and identified their phylogenetic relationships, 20th-century biologists used genetics, biochemistry, and large-scale genome sequencing to identify the catalog of human genes. Much work remains with this inventory because picking all human genes from a sequence of 3 billion DNA base pairs is incomplete and far from trivial. The initial count of 35 000 human genes may be short of the actual number. In addition, many genes originate . . . [Full Text of this Article]

An Agenda for Laboratory Research

Author Affiliation: Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Conn.

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