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To the Editor: The El Niño-Southern Oscillation (ENSO) has been related to patterns of vector-borne diseases such as malaria.¹ We studied the relationship between ENSO and hemorrhagic fever with renal syndrome (HFRS), a zoonosis caused by Hantaan or Hantaan-related virus, with characteristics of fever, hemorrhagic phenomena, kidney damage, and hypotension. Rodents, mostly mice, act as viral reservoirs and the source of infection. Although mice require moist soil, a large rainfall could have a negative impact on them by destroying their microenvironment.² Cases of HFRS have been found in Asia, Africa, Europe, and America. China has the most cases in the world, with over 1 million between 1950 and 1995. Anhui province has among the highest incidences in China.³

Methods

Information on the annual incidence of HFRS in Anhui province and China over the periods 1970-1996 and 1970-1995, respectively, were retrieved from Chinese public health data.³ The ENSO can be assessed by . . . [Full Text of this Article]

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