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Migraine as a Risk Factor for Subclinical Brain Lesions—Reply
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In Reply: Dr Zaidat is concerned about overfitting of our statistical model. In fact, when we adjusted only for age, education, and study site (model 1), the results were similar to when we adjusted for additional variables (model 2). Second, we concluded that migraine may increase the risk for silent brain lesions based on both the analyses of white matter lesions and detection of cerebellar infarcts. In the statistical analysis methods section we presented a power analysis for the infarcts. Our outcome was not the total number of brain lesions.
Interobserver reliability is not applicable, since there was only one reader, a senior neuroradiologist. Because the reader was blinded to the migraine diagnosis, we assume that the results were not biased by differential reading of the radiographic images.
We agree with Zaidat that valuable clinical data could aid in interpreting the results. Therefore, we described a number of demographic, clinical, . . . [Full Text of this Article]
Mark C. Kruit, MD
m.c.kruit@lumc.nl
Mark A. van Buchem, MD, PhD
Department of Radiology
Michel D. Ferrari, MD, PhD
Department of Neurology
Leiden University Medical Center
Leiden, the Netherlands
Lenore J. Launer, PhD
Laboratory of Epidemiology, Demography and Biometry
National Institute on Aging
National Institutes of Health
Bethesda, Md
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