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Richard B. Lipton, MD; Jullie Pan, MD, PhD

JAMA. 2004;291:493-494.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In this issue of THE JOURNAL, Kruit and colleagues¹ provide important new data on the prevalence of brain infarction and white matter lesions in persons with migraine. The authors systematically recruited individuals with migraine with aura and migraine without aura as well as group-matched controls without migraine from the general Dutch population. By using population surveys, the authors identified a representative sample of migraine cases, addressing concerns about selection bias in earlier studies.^2-4 An appropriate population control group without migraine was recruited from the screened sample. The use of 3-mm magnetic resonance imaging (MRI) sections improved lesion detection, and imaging studies were interpreted masked to case status, minimizing bias in the assessment of radiographic findings. Demographic factors, cardiovascular diseases, headache features, and treatment patterns were carefully assessed so that these potential confounders and effect modifiers could be taken into account.

Using these . . . [Full Text of this Article]

Author Affiliation: Departments of Neurology, Epidemiology and Public Health (Dr Lipton) and Neuroscience (Dr Pan), Albert Einstein College of Medicine, Bronx, NY.

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