This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (1)  • Contact me when this article is cited  Related Content  • Related articles  • Similar articles in JAMA  Topic Collections  • Statistics and Research Methods  • Women's Health  • Women's Health, Other  • Alert me on articles by topic  Social Bookmarking   What's this?

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To the Editor: I am concerned that the study by Dr Kreijkamp-Kaspers et al¹ may have failed to ensure adequate vitamin D intake and to control for serum 25-hydroxyvitamin D status among its participants. The data presented in Table 3 of the article indicate that vitamin D intake in the treatment group actually decreased from 4.27 µg (171 IU) to 3.54 µg (142 IU) during the study period. Vitamin D intake at this level would be insufficient to maintain minimum serum vitamin D levels and to sustain bone health, with a daily intake of 1000 IU suggested as the minimal dose to prevent osteoporosis.² In addition, the city of Utrecht, from which their patient population was selected, is located in a region with a high incidence of hypovitaminosis D.^2-4

Dave N. Muanza, PhD; Alex Vasquez, BS
drdmuanza@bioticsresearch.com
Biotics Research Corporation
Rosenberg, Tex

John Cannell, MD
Atascadero, Calif

William P. Grant, PhD
Newport News, Va

1. Kreijkamp-Kaspers S, Kok L, Grobbee DE, et al. Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: a randomized controlled trial. JAMA. 2004;292:65-74. FREE FULL TEXT 2. Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr. 2004;79:362-371. FREE FULL TEXT 3. McKenna MJ. Differences in vitamin D status between countries in young adults and the elderly. Am J Med. 1992;93:69-77. FULL TEXT | ISI | PUBMED 4. Dubbelman R, Jonxis JH, Muskiet FA, Saleh AE. Age-dependent vitamin D status and vertebral condition of white women living in Curacao (The Netherlands Antilles) as compared with their counterparts in The Netherlands. Am J Clin Nutr. 1993;58:106-109. FREE FULL TEXT

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292:2337.

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