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Does the Metabolic Syndrome Really Exist?
Diabetes and Heart Disease Groups Spar Over Issue
Mike Mitka
JAMA. 2005;294:2010-2013.
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Is the cluster of diabetes and heart disease risk factors known as the metabolic syndrome a thoroughly studied, robust, and clinically useful tool? Or is it a poorly defined set of conditions that can possibly mislead physicians trying to prevent those conditions?
The battle over the issue has been joined. On one side are the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD); on the other, the American Heart Association (AHA) and the National Heart, Lung, and Blood Institute (NHLBI).
EMPEROR’S NEW CLOTHES?
The ADA and the EASD fired the first shot in late August with publication of a joint statement, based on a literature review, that concluded that the metabolic syndrome has been imprecisely defined (Kahn et al. Diabetes Care. 2005;28:2289-2304). "There is a lack of certainty regarding its pathogenesis, and there is considerable doubt regarding its value as a [cardiovascular disease] risk marker," . . . [Full Text of this Article]
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