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Steven E. Come, MD, Discussant

JAMA. 2006;295:1434-1442.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

DR BURNS: Ms T is a 62-year-old woman with a new diagnosis of left breast cancer. A routine mammogram performed in the fall of 2004 revealed a 9-mm spiculated mass deep within the upper inner quadrant of her left breast. Prior annual mammograms had been normal. No mass was palpable in this area, but ultrasound demonstrated a hypoechoic mass at 10 o’clock a few centimeters from the nipple. A stereotactic core biopsy was performed and disclosed an infiltrating lobular carcinoma.

Her medical history was otherwise noteworthy for recurrent bouts of diverticulitis and osteopenia. She experienced menarche at 12 years of age. She has 2 children and was 21 years old at the birth of her first child. She briefly used oral contraceptives and never used fertility medications. She experienced menopause in her early 50s and took hormone therapy for 1 . . . [Full Text of this Article]

MS T: HER VIEW

Adjuvant Endocrine Therapy and Disease-Free and Overall Survival

Tamoxifen

Aromatase Inhibitors

Aromatase Inhibitors vs Tamoxifen

Aromatase Inhibitors as an Alternative to Tamoxifen

Sequential Use of Tamoxifen and Aromatase Inhibitors

Duration of Adjuvant Endocrine Therapy

Adverse Effects and Costs

What Does the Future Hold?

Author Affiliation: Dr Come is Associate Professor of Medicine, Harvard Medical School, and Medical Director, Breast Cancer Program, Beth Israel Deaconess Medical Center, Boston, Mass.

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