 |
|
Growth Hormone for "Antiaging"
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
To the Editor: We disagree with the arguments put forward in the Commentary by Dr Perls and colleagues1 to oppose the widespread use of GH replacement for elderly GH deficiency (GHD). First, the authors suggest that GH replacement is associated with substantial adverse effects. Wuster et al demonstrated that such adverse effects may be due to overdosing and can be avoided by reducing the dose of GH by 50%.2
Second, a central point of Perls et al is that GH may cause cancer in humans, but this has never been proven. In a cohort study, GH replacement used in children treated for a malignant brain tumor was associated with a decrease in tumor recurrence by 40% and overall mortality rate by 50% in the first 5 years after diagnosis.3 The use of GH in adult patients with malignant gastrointestinal tumors did not increase tumor recurrence or decrease mean survival time.4 . . . [Full Text of this Article]
Claude Dalle, MD
cldalle@wanadoo.fr
Vaujours, France
Vicario Claude, MD
Autonomous University of Barcelona
Barcelona, Spain
RELATED ARTICLES
Growth Hormone for "Antiaging"
Thierry Hertoghe and Suzie Schuder
JAMA. 2006;295(8):888.
EXTRACT
| FULL TEXT
Growth Hormone for "Antiaging"
Bernhard Sauter
JAMA. 2006;295(8):889.
EXTRACT
| FULL TEXT
Growth Hormone for "Antiaging"—Reply
Thomas Perls, Neal R. Reisman, and S. Jay Olshansky
JAMA. 2006;295(8):889-890.
EXTRACT
| FULL TEXT
Provision or Distribution of Growth Hormone for "Antiaging": Clinical and Legal Issues
Thomas T. Perls, Neal R. Reisman, and S. Jay Olshansky
JAMA. 2005;294(16):2086-2090.
EXTRACT
| FULL TEXT
|
