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Medical Implications of the Male Biological Clock
Benjamin H. Lewis, MD;
Marianne Legato, MD;
Harry Fisch, MD
JAMA. 2006;296:2369-2371.
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The phrase "biological clock" is most commonly used by physicians to refer to the declining fertility, increasing risk for fetal birth defects, and altered hormone levels experienced by women as they age. Abundant scientific evidence suggests that men also may have a biological clock.1-2 Men and their physicians must therefore understand the effects of the male biological clock on sexual and reproductive health, as well as its potential contributions to major medical consequences such as diabetes, cardiovascular disease, and the metabolic syndrome.
Aging, Male Infertility, and Birth Defects in Offspring
Male fertility clearly declines with age.3 Studies demonstrate that men older than 35 years are twice as likely to be infertile (defined as the inability to initiate a pregnancy within 12 months) as men younger than 25 years.4 Among couples undergoing fertility treatments with intrauterine insemination, the amount of time necessary to achieve a pregnancy increases significantly with . . . [Full Text of this Article]
Author Affiliations: Department of Medicine (Drs Lewis and Legato) and Department of Urology and Male Reproductive Center (Dr Fisch), Columbia University Medical Center/New York Presbyterian Hospital, New York, NY.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Improving Men's Health: Evidence and Opportunity.
Fontanarosa and Cole
JAMA 2006;296:2373-2375.
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