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A New Challenge for Preventive Medicine

Kenneth Offit, MD, MPH; Michal Sagi, PhD; Karen Hurley, PhD

JAMA. 2006;296:2727-2730.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Over the next decade, health care professionals may increasingly be involved in discussions of reproductive options when providing preventive medicine guidance to patients and their families affected by hereditary cancer syndromes. Preimplantation genetic diagnosis (PGD) is one means of assisted reproductive technology (ART) wherein embryos that do not inherit a familial mutation are selected for implantation and gestation. Recently, we documented 55 published reports as well as unpublished experiences using ART for 22 common predisposition syndromes, including hereditary breast, ovarian, and colon cancer.¹

Because progress in PGD has occurred only recently, guiding reproductive choice with cancer genetic tests has not been included in professional guidelines.² Herein we outline some of the regulatory, ethical, and social issues raised by the introduction of PGD into routine care of families affected by hereditary cancer. We offer an analytic framework to address these issues . . . [Full Text of this Article]

Factors Driving Uptake of ART in the Setting of Cancer Syndromes

Author Affiliations: Clinical Genetics Service, Department of Medicine (Dr Offit) and Department of Psychiatry (Dr Hurley), Memorial Sloan-Kettering Cancer Center, New York, NY; and Department of Human Genetics, Hadassah-Hebrew University Hospital, Jerusalem, Israel (Dr Sagi).

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