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Radiation Exposure and Thyroid Cancer
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To the Editor: In his Editorial, Dr Boice1 draws what we believe to be unsupportable conclusions about the relation between iodine 131 and thyroid disease. He states that the evidence for iodine 131 and thyroid cancer from the Chernobyl nuclear disaster is not straightforward due to the presence of other iodine isotopes that could have contributed to excess risk, yet there is strong evidence that isotopes other than iodine 131 delivered at most only a few percent of the total dose to the thyroid of exposed persons.2 Boice alludes to possible interactions between radioiodine exposure and iodine deficiency but notes no evidence that iodine deficiency and potassium iodide act independently in modifying iodine 131–related thyroid cancer risk.2
Of the Hanford Thyroid Disease Study (HTDS),3 Boice states that HTDS results indicate that childhood exposures to prolonged releases of pure iodine 131 are associated with a risk of radiation-induced thyroid cancer that . . . [Full Text of this Article]
F. Owen Hoffman, PhD
senesor@senes.com
SENES Oak Ridge Inc
Oak Ridge, Tenn
A. James Ruttenber, PhD, MD
Department of Preventive Medicine & Biometrics
University of Colorado School of Medicine
Denver
Sander Greenland, MA, MS, DrPH, CStat
Department of Epidemiology
University of California
Los Angeles
Raymond J. Carroll, PhD
Department of Statistics
Texas A&M University
College Station
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