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M. J. Friedrich

JAMA. 2007;297(20):2187.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Malaria researchers studying the Anopheles mosquito's physiology, behavior, and ecology are hoping such studies will lead to improved methods for controlling the disease.

One promising approach involves the creation of transgenic mosquitoes that are resistant to infection with the malarial parasite. Researchers at Johns Hopkins Malaria Research Institute, in Baltimore, recently found that a malaria-resistant designer mosquito they developed in 2002 could outcompete its wild-type counterparts when fed malaria-infected blood from mice (Marrelli MT et al. Proc Natl Acad Sci U S A. 2007;104:5580-5583). The nonresistant mosquitoes carrying parasites laid fewer eggs and did not live as long as the transgenic mosquitoes.

Scientists are exploring ways to control malaria by targeting the mosquito vector. (Photo credit: James Gathany/CDC)

"This was the first time that a transgenic mosquito was shown to do better than a nontransgenic insect in terms of fitness," said Frederick Tripet, PhD, lecturer in molecular . . . [Full Text of this Article]

SPREADING RESISTANCE

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