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Joan Stephenson, PhD

JAMA. 2007;297:254.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Two randomized, controlled trials in Africa on the effect of adult male circumcision on HIV transmission, conducted by researchers from Canada, Kenya, Uganda, and the United States, were halted last month when an interim review of the trial data showed that the procedure significantly reduces a man's risk of becoming infected with HIV through heterosexual intercourse.

In a trial in Kenya involving 2784 HIV-negative men, 47 uncircumcised men became infected compared with 22 among the circumcised men, a 53% reduction. In a trial in Uganda involving 4996 HIV-negative men, 43 uncircumcised men acquired HIV compared with 22 among the circumcised men, a 48% reduction.

Health experts emphasized that circumcision should not replace other prevention strategies. "This must not reduce our emphasis on other preventive interventions, behavioral interventions, regular and consistent use of condoms, said Kevin De Cock, MD, director of the World Health Organization's (WHO’s) department of . . . [Full Text of this Article]