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In Search of the Holy Grail

Commentary by Louis R. Pasquale, MD

JAMA. 2007;297:306-307.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Archives of Ophthalmology

Identification of Novel Genetic Loci for Intraocular Pressure: A Genomewide Scan of the Beaver Dam Eye Study

Priya Duggal, MD, MPH; Alison P. Klein, PhD; Kristine E. Lee, MS; Ronald Klein, MD, MPH; Barbara E. K. Klein, MD, MPH; Joan E. Bailey-Wilson, PhD

Objective: To identify genetic loci that control intraocular pressure (IOP).

Methods: We performed a genomewide scan of IOP, using 486 pedigrees ascertained through a population-based cohort, the Beaver Dam Eye Study. Linkage analysis was performed using the modified Haseman-Elston regression models and variance components linkage analysis.

Results: Seven regions of interest were identified on chromosomes 2, 5, 6, 7, 12, 15, and 19. The novel linkage region on chromosome 19p had an empirical multipoint P value of 6.1 x 10^–5. Two of the regions (2 and 19) were especially interesting since each has been identified as a . . . [Full Text of this Article]