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To the Editor: The prospective cohort study by Dr Gelfand and colleagues¹ found that patients with psoriasis had an increased adjusted relative risk for myocardial infarction (MI). In their conclusion, the authors state that psoriasis may confer an independent risk of MI, which is greater in young patients with severe psoriasis. Analyses were performed using conditional logistic regression, adjusted for age, sex, and other major cardiovascular risk factors (hypertension, diabetes, history of MI, hyperlipidemia, smoking, and body mass index).

Other studies have demonstrated the association of psoriasis with severe psychological morbidity, in particular with depression. Devrimci-Ozguven et al² demonstrated that patients with psoriasis had significantly higher degrees of depression and more body cathexis problems than did controls. Esposito et al³ reported that psoriasis is associated with profound psychological morbidity (particularly with depression) in a large number of patients. In addition, depression is an independent risk factor for coronary heart disease . . . [Full Text of this Article]

Alevizos Alevizos, MD
alevisos@gmail.com
Department of General Practice and Family Medicine
Health Centre of Vyronas

Georgios Larios, MD
Department of Dermatology
"A. Sygros" Hospital

Anargiros Mariolis, MD, PhD
Department of General Practice and Family Medicine
Health Centre of Vyronas
Athens, Greece

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