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Genetic Testing in Diverse PopulationsAre Researchers Doing Enough to Get Out the Correct Message?
Dezheng Huo, MD, PhD;
Olufunmilayo I. Olopade, MD
JAMA. 2007;298(24):2910-2911.
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More than 10 years after BRCA1 and BRCA2 were discovered as major breast cancer susceptibility genes, the medical community is just beginning to get a glimpse of how germline mutations in these genes might be distributed among racial/ethnic minority populations in the United States. While a growing body of evidence documents the benefits of preventive measures having minimal risk for women with identifiable BRCA1 and BRCA2 mutations, genetic testing services remain underutilized by minority women. In this issue of JAMA, John and colleagues1 provide information regarding the prevalence of pathogenic BRCA1 mutations in a population-based study among 5 US racial/ethnic groups in Northern California. Prevalence was particularly high among young African Americans, a group that has long been recognized as having a disproportionate burden of aggressive young-onset breast cancer.
With more than 200 000 women estimated to be diagnosed with breast cancer . . . [Full Text of this Article]
Author Affiliation: Department of Medicine, University of Chicago, Chicago, Illinois.
RELATED ARTICLE
Prevalence of Pathogenic BRCA1 Mutation Carriers in 5 US Racial/Ethnic Groups
Esther M. John, Alexander Miron, Gail Gong, Amanda I. Phipps, Anna Felberg, Frederick P. Li, Dee W. West, and Alice S. Whittemore
JAMA. 2007;298(24):2869-2876.
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