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Tracy Hampton, PhD

JAMA. 2007;298:394.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

A number of genes are expressed at high levels only in the blood vessels that feed tumors, according to studies in mice and humans by investigators at the National Cancer Institute's facility in Frederick, Md (Seaman et al. Cancer Cell. 2007;11[6]:539-554). The finding may be useful for advancing antiangiogenesis strategies, approaches that aim to disrupt the growing blood vessels that support tumor growth.

Current vascular-targeted therapies may damage normal growing blood vessels, but the identification of genes that are highly active specifically in vessels that supply tumors may help scientists develop therapies that primarily target vessels associated with cancer.

The researchers compared the gene expression patterns of endothelial cells from normal mouse livers and from tumor-bearing livers, finding 13 distinct genes that were overexpressed during cancer-related angiogenesis. Among the genes identified was CD276, which encodes a cell-surface protein thought to be involved in regulating inflammatory . . . [Full Text of this Article]