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Prevalent Vertebral Fracture and the Risk of Incident Vertebral Fracture
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To the Editor: In their study of long-term risk of incident vertebral fractures, Dr Cauley and colleagues1 concluded that older women with a prevalent vertebral fracture had a substantially increased absolute risk of an incident fracture, particularly if they had osteoporosis diagnosed by bone mineral density assessment.1 In this study, it appears that both symptomatic and asymptomatic women with a prevalent vertebral fracture at baseline were combined.
Only about one-third of vertebral fractures are clinically recognized.2 Because of this, it would be valuable to know the absolute risk of an incident fracture for symptomatic and asymptomatic women separately. Symptomatic women with a prevalent fracture at baseline may have had more opportunity to receive medication for osteoporosis than asymptomatic women who were diagnosed only by radiographs. This might result in a lower absolute risk of incident fracture among symptomatic women. In addition, the odds ratio (OR) for incident fracture in asymptomatic . . . [Full Text of this Article]
Akira Taguchi, DDS, PhD
akiro@hiroshima-u.ac.jp
Department of Oral and Maxillofacial Radiology
Hiroshima University Hospital
Hiroshima, Japan
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