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In Reply: We appreciate the comments of Drs Anghelescu and Regen regarding the TORDIA study. With respect to the switching strategy, we chose a conservative approach in this adolescent population rather than extrapolate from a strategy used in adults. Because our study was not placebo-controlled, the results from TORDIA cannot directly address the question of suicidality and antidepressant use. However, prospective studies specifically designed to address this issue are warranted.

Financial Disclosures: Dr Wagner reported past research support from Abbott Laboratories, AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Forest Laboratories, GlaxoSmithKline, Johnson & Johnson, Novartis, Organon, Pfizer, and Wyeth-Ayerst; and being a consultant/advisory board member for Abbott Laboratories, AstraZeneca, Bristol-Myers Squibb, Cyberonics, Eli Lilly, Forest Laboratories, GlaxoSmithKline, Janssen, Jazz Pharmaceuticals, Novartis, Ortho-McNeil, Pfizer, Organon, Otsuka, Solvay, UCB Pharma, Wyeth Ayerst. No other financial disclosures were reported.

David Brent, MD
brentda@upmc.edu
Department of Psychiatry
University of Pittsburgh
Pittsburgh, Pennsylvania

Karen Dineen Wagner, MD, PhD
University of Texas Medical Branch
Galveston

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2008;299(23):2746.

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Switching to Another SSRI or to Venlafaxine With or Without Cognitive Behavioral Therapy for Adolescents With SSRI-Resistant Depression: The TORDIA Randomized Controlled Trial
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SSRI Tapering and Suicidal Ideation in the TORDIA Study for Treatment of Depressed Adolescents
Ion Anghelescu and Francesca Regen
JAMA. 2008;299(23):2745-2746.
EXTRACT | FULL TEXT