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To the Editor: I am writing to inform the editors and readers of JAMA of errors in a study of conventional-dose vs high-dose conformal radiation therapy in clinically localized prostate cancer, published in the September 14, 2005, issue of JAMA, for which I was principal investigator.¹

These errors were uncovered in the process of working on a series of secondary analyses for which access to the raw data was needed. All of the original data had been collected, stored, and analyzed by the statistics department of the American College of Radiology (ACR). For one secondary analysis, the raw data were obtained from the ACR and the original Kaplan-Meier analysis of cancer-free survival was rerun. This outcome had been defined as freedom from 3 successive increases in the level of prostate-specific antigen (PSA). We were unable to reproduce the curves reported in the JAMA article and brought this to the . . . [Full Text of this Article]

Anthony L. Zietman, MD
azietman@partners.org
Department of Radiation Oncology
Massachusetts General Hospital
Boston

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Comparison of Conventional-Dose vs High-Dose Conformal Radiation Therapy in Clinically Localized Adenocarcinoma of the Prostate: A Randomized Controlled Trial
Anthony L. Zietman, Michelle L. DeSilvio, Jerry D. Slater, Carl J. Rossi, Jr, Daniel W. Miller, Judith A. Adams, and William U. Shipley
JAMA. 2005;294(10):1233-1239.
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