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Are We on the Verge of Global Eradication?

Commentary by Stephen L. Cochi, MD, MPH; Olen Kew, PhD

JAMA. 2008;300(7):839-841.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

SUMMARY OF THE ORIGINAL ARTICLE

Studies in Human Subjects on Active Immunization Against Poliomyelitis

Jonas E. Salk, MD; MAJ Byron L. Bennett, US Army (ret); L. James Lewis, PhD; Elsie N. Ward, MA; J.S. Youngner, ScD

JAMA. 1953;151(13):1081-1098

In 1953 at the height of polio epidemics in the United States, Salk and colleagues described preliminary findings that led to an inactivated poliovirus vaccine. After review of the scientific evidence favoring artificial immunization against polio, the systematic experimental approach to vaccine development was outlined in detail including the criteria for selection of the vaccine strains, the choice of monkey kidney cells for vaccine virus production in tissue culture, and the inactivation of infectivity by incubation of clarified virus preparations in a 1:250 formalin at 1°C for 7 to 10 days.

Preliminary results were reported on the levels of neutralizing . . . [Full Text of this Article]