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JAMA. 2009;302(10):1105-1106.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In the first of 136 Clinical Crossroads articles published in JAMA since 1995, Peter C. Albertsen, MD, discussed Mr S, a 72-year-old man with localized prostate cancer.¹

In 1992, Mr S was found by Dr K, his primary physician, to have slight induration of his prostate on a routine physical examination. A consulting urologist confirmed the finding and suggested a prostate biopsy after noting an elevated prostate-specific antigen (PSA) value of 4.3 ng/mL. Needle biopsy performed in 1992 was "suspicious for adenocarcinoma, but not diagnostic," but repeat biopsy 1 year later revealed adenocarcinoma in 2 of 8 cores: 1 with a "minute focus" and 1 with a "small focus." The areas with carcinoma were read as Gleason 3 + 3, and another area revealed "high-grade intraepithelial neoplasia." Evaluation for metastases was negative, and prostate volume was measured as 32 cm³. A repeat PSA value was 3.8 ng/mL. In February 1994, Mr . . . [Full Text of this Article]

DR K

Tom Delbanco, MD; Peter C. Albertsen, MD

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