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To the Editor: Bronchopulmonary dysplasia (BPD) is the primary respiratory complication of premature birth, associated with a reduced maximal lung function that may carry a risk of a chronic obstructive pulmonary disease (COPD)–like phenotype developing later in life.¹ There is little prospective evidence about the evolution of lung function in long-term survivors of BPD.

Methods

This prospective study was performed between October 1992 and April 2008 with 17 survivors of BPD. Maximum flow at functional residual capacity (Vmax_FRC) was measured at age 2 years² and lung function at ages 9³ and 15 years. Bronchopulmonary dysplasia was defined as oxygen dependence persisting at 28 days in infants born with a weight less than 1250 g.³

Two control groups matched for sex and age (within 6 months) comprised 34 healthy children born at term and 17 children born preterm without BPD who had spirometry performed at age 9 years and again at . . . [Full Text of this Article]

Marco Filippone, MD; Gea Bonetto, MD; Emanuele Cherubin, MD; Silvia Carraro, MD; Eugenio Baraldi, MD
baraldi@pediatria.unipd.it
Department of Pediatrics
University of Padua School of Medicine
Padua, Italy

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