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David A. Kaufman, MD

JAMA. 2009;302(13):1467-1468.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The study by Manzoni and colleagues¹ in this issue of JAMA represents an important step toward preventing infections that currently pose a major hurdle for preterm infants. The findings give insight into the role of lactoferrin in preventing infection, helping to define its importance in breast milk as well as the effect of daily supplementation with bovine lactoferrin (BLF) in preterm infants.

The incidence of late-onset (>72 hours of age) bloodstream infections in very low-birth-weight (VLBW) infants (<1500 g) is approximately 20% and is complicated by high mortality and neurodevelopmental impairment.^2-3 In the United States, nearly 65 000 VLBW infants are born each year, which translates into approximately 13 000 infections, 2300 deaths, and neurodevelopmental impairment in 3000 survivors.⁴ For the smallest infants of extremely low birth weight (ELBW) (<1000 g), neurodevelopmental impairment occurs in 45% of those who survive bacteremia and 57% of those who survive fungemia.³ . . . [Full Text of this Article]

Author Affiliations: Division of Neonatology, Department of Pediatrics, University of Virginia Health System, Charlottesville.

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RELATED ARTICLE

Bovine Lactoferrin Supplementation for Prevention of Late-Onset Sepsis in Very Low-Birth-Weight Neonates: A Randomized Trial
Paolo Manzoni, Matteo Rinaldi, Silvia Cattani, Lorenza Pugni, Mario Giovanni Romeo, Hubert Messner, Ilaria Stolfi, Lidia Decembrino, Nicola Laforgia, Federica Vagnarelli, Luigi Memo, Linda Bordignon, Onofrio Sergio Saia, Milena Maule, Elena Gallo, Michael Mostert, Cristiana Magnani, Michele Quercia, Lina Bollani, Roberto Pedicino, Livia Renzullo, Pasqua Betta, Fabio Mosca, Fabrizio Ferrari, Rosario Magaldi, Mauro Stronati, Daniele Farina, and for the Italian Task Force for the Study and Prevention of Neonatal Fungal Infections, the Italian Society of Neonatology
JAMA. 2009;302(13):1421-1428.
ABSTRACT | FULL TEXT  

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Lactoferrin and Sepsis: Good News for Low Birth Weight Infants
JWatch Pediatrics 2009;2009:1-1.
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