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Thomas K. Hunt, MD; Harriet W. Hopf, MD

JAMA. 2009;302(14):1588-1589.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Evidence continues to accumulate on whether the use of high inspired oxygen fraction (FIO₂) is effective for preventing surgical site infections (SSIs). In 2000, a randomized trial by Greif et al¹ demonstrated that SSIs were significantly decreased following colon surgery in patients who received 80% oxygen intraoperatively and for the first 2 hours following surgery. Subsequent clinical trials by Belda et al² and by Myles et al³ supported the use of perioperative supplemental high inspired oxygen for reducing risk of surgical wound infection, whereas a clinical trial by Pryor et al⁴ suggested that perioperative hyperoxia was not effective in reducing SSIs (and in fact increased them). A trial by Mayzler et al⁵ reported only 5 of 38 patients as developing SSI overall and thus had inadequate power to draw conclusions. A meta-analysis⁶ of these trials, pooling the outcomes of 3001 . . . [Full Text of this Article]

Author Affiliations: Department of Surgery, University of California, San Francisco (Dr Hunt); and Departments of Anesthesiology and Bioengineering, University of Utah School of Medicine, Salt Lake City (Dr Hopf).

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