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Commentary by R. Palmer Beasley, MD, MS

JAMA. 2009;302(3):322-324.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

SUMMARY OF THE ORIGINAL ARTICLE

Vaccine Against Human Hepatitis B

Eugene B. Buynak, PhD; Robert R. Roehm; Alfred A. Tytell, PhD; Alexander U. Bertland II, PhD; George P. Lampson, MS; Maurice R. Hilleman, PhD, DSc

JAMA. 1976;235(26):2832-2834.

A highly purified and inactivated vaccine was made of hepatitis B virus surface antigen. The vaccine was tested exhaustively for safety by ordinary procedures and additionally in chimpanzees and marmosets. It was highly potent and induced antibody in guinea pigs, grivet monkeys, and chimpanzees after three doses of vaccine were given subcutaneously. Chimpanzees given three doses of vaccine were protected against challenge with 1000 chimpanzee-infectious doses of live human hepatitis B virus given intravenously in controlled studies. Tests of the vaccine for control of hepatitis B in man are to be carried out.

See PDF for full text of the original JAMA article.

Author Affiliation: Division of Epidemiology and Disease Control, University of Texas School of Public Health, Houston.

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