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Boris Pasche, MD, PhD; Richard M. Myers, PhD

JAMA. 2009;302(3):325-326.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Cancer is a disease of the genome at the level of gene expression, epigenetic modifications such as DNA methylation, and DNA alterations. For more than 3 decades, many lines of research have shown that acquisition of genetic changes is a major and required step in the development of most cancers. First, ionizing radiation and chemicals that damage DNA and cause mutations also cause cancer.¹ Second, genomic alterations such as translocations that result in the production of a specific gene fusion product are associated with some types of cancer. Such is the case for the translocations between chromosomes 9 and 22 in chronic myeloid leukemia and the translocation between chromosomes 15 and 17 in acute promyelocytic leukemia.² Third, the introduction of genomic DNA from human cancer cells into normal cells can render the normal cells cancerous.³

In the past 2 decades, many genomic . . . [Full Text of this Article]

Author Affiliations: Division of Hematology/Oncology, University of Alabama at Birmingham, and UAB Comprehensive Cancer Center, Birmingham (Dr Pasche); and HudsonAlpha Institute for Biotechnology, Huntsville, Alabama (Mr Myers). Dr Pasche is also Contributing Editor, JAMA.

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