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Paul T. Costa, Jr, PhD; Alan B. Zonderman, PhD; Robert R. McCrae, PhD
National Institute on Aging National Institutes of Health Baltimore, Md

JAMA. 1990;263(4):514.

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In Reply. —

In her response to our recent article, Dr Andrianopoulos suggests that depression may be a risk factor for a subgroup of cancers that are sensitive to immunodeficiency. We did not present analyses by site or type of cancer because we did not have sufficient numbers of cases to conduct conclusive analyses. Of the 637 cases of any diagnosis of cancer, only 71 (11%) were of the types specified by Dr Andrianopoulos. Most of these (47) were carcinomas of the lip and skin. New proportional hazards analyses, with and without adjustment for standard risk factors, showed no significant association between depressive symptoms on the General Well-being Schedule and these types of cancer (relative risk, 1.1), nor was there a significant association when the Center for Epidemiological Studies Depression scale was examined. Even with the small number of cases in these analyses, it appears fair to conclude that if . . . [Full Text PDF of this Article]

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